Asymmetric Control of Food Intake by Left and Right Vagal Sensory Neurons.

Left and right vagus nerves provide different sensory information about a meal to the brain. Both anatomical and behavioral feeding studies support the necessity and sufficiency LNG neurons as food quantity detectors and RNG neurons as food reward mediators - which has less influence on how much is consumed but rather plays a role in the decision-making process about which foods to consume. Our findings on asymmetrical vagal innervation of the gut provides new mechanistic insight for how feeding decisions are made in response to vast and complex meal-related signals.