Id: 3521589 sprite zero for better gastric preparation for capsule endoscopy examination: a randomized controlled pilot study

ID: 3521589 SPRITE ZERO FOR BETTER GASTRIC PREPARATION FOR CAPSULE ENDOSCOPY EXAMINATION: A RANDOMIZED CONTROLLED PILOT STUDY Jia-Hui Zhu, Yang-Yang Qian, Xiao Liu, Zhuan Liao* Introduction: As noninvasive and well-tolerated, magnetically controlled capsule endoscopy (MCE) is widely applied clinically. However, there still requires attention including abdominal distension, insufficient gastric filling and gastric retention. We aimed to compare the feasibility of 400ml Sprite Zero , which can release CO2 with 800ml water, the normal gastric preparation strategy for MCE. Methods: We performed a pilot, open-label, randomized controlled trial at the Endoscopy Center of Changhai Hospital in Shanghai from December 16th, 2019 to January 15th, 2020 with the approval of Ethics Committee of Changhai Hospital. Consecutive patients scheduled to MCE examination with informed consents were randomly assigned to Sprite(S) group or water (W) group with 1:1 ratio consecutively. All patients ingested 400 mg simethicone suspension dissolved in 100 mL water 40 minutes before swallowing capsule. In W group, patients were required to drink 800 mL pure water 10 minutes before swallowing capsule. And for patients in the S group, 400 ml Sprite Zero (SpriteTM soft drink, The Coca-Cola Company, China) were provided for gastric filling. Then, patients put on the data recorder and swallow capsules. MCE examination were performed by the same endoscopist (W.Z.). The primary endpoint was the degree of gastric filling evaluated by the height of gastric mucosal folds and the distance between the adjacent mucosal folds under MCE . Secondary endpoints included the feeling of fullness assessed by visual analogue scale (VAS), gastric transit time (GTT), small bowel transit time (SBTT), completion rate (CR) for small bowel examination and diagnostic yield (DY). The safety was evaluated after a twoweek follow-up period after procedure in case of adverse events. Result: We enrolled 52 patients in S group and 50 patients in W group (Table 1). No adverse events related to capsule were observed. The median score of gastric filling during 0-5 min, 5-10 min and 10-15 min under MCE in S group were all 4.0, the same as those in W group. The amount of liquid intake in S group was fewer than that in W group with a lower feeling of fullness score (7.0 vs 7.5, PZ0.047). The CR of small bowel examination in S group was 100% while in W group was 89.66% (PZ0.245). Although there were no significant differences between S group and W group in GTT and SBTT, the proportion of patients with GTT less than 30 minutes in S group were significantly increased than that in W group (69.57% vs 27.59%, PZ0.03). Conclusion: This pilot study provided a preliminary clinical assessment of a novel gastric preparation strategy for MCE. The results showed that 400 ml Sprite Zero displayed similar gastric filling with improved comfortableness and potential effect in relieving gastric retention of capsule compared with 800 ml water. FRIDAY, MAY 21, 2021 Clinical Endoscopic Practice 2 Lecture