Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia

1 Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio . 2 Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan. 3 Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio. 4 Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. 5 Division of Hematologic Malignancies, Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut. 6 Department of Hematology, and Clinical Trial Center, Erasmus University Medical Center, Rotterdam, the Netherlands. 7 Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine/Montefi ore Medical Center, Bronx, New York. 8 Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York. 9 Blood and Marrow Transplantation, Moffi tt Cancer Center, Oncologic Sciences, College of Medicine at University of South Florida, Tampa, Florida. 10 Department of Medicine, Hematology/Oncology Division, Weill Cornell Medical College, New York, New York. 11 Section of Hematology/Oncology, and the Comprehensive Cancer Center, University of Chicago, Chicago, Illinois. 12 Department of Laboratory Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California. 13 Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio.