The Prevalence of Depression and Anxiety in Women with Ovarian Cancer: An Updated Systematic Review and Meta-Analysis of Cross-Sectional Studies

Background: This study aimed to determine the pooled prevalence of anxiety and depression in women with ovarian cancer.Methods: Databases (PubMed [Medline], Scopus, Web of Science, Embase, and PsycInfo) were searched to retrieve all cross-sectional studies between July 2013 and October 2021. All analyses were performed using STATA 16, and the random-effects model was applied to calculate the pooled prevalence with a 95% confidence interval (95%CI).Results: Out of the 18 selected cross-sectional studies, 17 reported depression prevalence, and 16 reported anxiety prevalence in women with ovarian cancer. The pooled prevalence of depression and anxiety was 27% (95%CI: 14%-41%; I2=69.44%) and 33% (95%CI: 21%-44%; I2=78.55%), respectively.Conclusion: Based on this result, the prevalence of depression and anxiety in women with ovarian cancer was higher than in the healthy female population. Thus, health policymakers should provide the facilities for doing more studies such as cohorts to measure the effect of various treatments or interventions to reduce the mental disorders in women with ovarian cancer.