Fecal concentration of intravenous vancomycin preparation after oral administration in an experimental model: preclinical assay.

J Ramos-García, F Robles-Rivera, M Chávez-Soto,M Valdés, F Calzada,N Ortiz-Olvera

Revista de gastroenterologia de Mexico (English)（2022）

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摘要

The fecal concentration of vancomycin was dependent on the intragastric dose administered. Only the 500 mg dose of VCM reached therapeutic concentration for C. difficile (MIC and MBC), in the mice. We suggest starting a dose of 500 mg QID for achieving therapeutic concentration against C. difficile, as soon as 4 h after the first dose.

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关键词

Clostridioides difficile,Concentración bactericida mínima,Concentración fecal,Ensayo preclínico,Fecal concentration,Minimum bactericidal concentration,Preclinical assay,Vancomicina,Vancomycin

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