Precise Design of Atomically Dispersed Fe, Pt Dinuclear Catalysts and Their Synergistic Application for Tumor Catalytic Therapy

Recently, extending single-atom catalysts from mono- to binary sites has been proved to be a promising way to realize more efficient chemical catalytic processes. In this work, atomically dispersed Fe, Pt dinuclear catalysts ((Fe, Pt) sA -N-C) with an ca. 2.38 A distance for Fe, (Fe-N-3) and Pt, (Pt-N-4) could be precisely controlled via a novel secondary-doping strategy. In response to tumor microenvironments, the Fe-N-3/Pt-N-4 moieties exhibited synergistic catalytic performance for tumor catalytic therapy. Due to its beneficial microstructure and abundant active sites, the Fe-N-3 moiety effectively initiated the intratumoral Fenton-like reaction to release a large amount of toxic hydroxyl radicals (*OH), which further induced tumor cell apoptosis. Meanwhile, the bonded PtN4 moiety could also enhance the Fenton-like activity of the Fe-N-3 moiety up to 128.8% by modulating the 3d electronic orbitals of isolated Fe-N-3 sites. In addition, the existence of amorphous carbon revealed high photothermal conversion efficiency when exposed to an 808 nm laser, which synergistically achieved an effective oncotherapy outcome. Therefore, the as-obtained (Fe, Pt) sA -N-C-FA-PEG has promising potential in the bio-nanomedicine field for inhibiting tumor cell growth in vitro and in vivo.