A parallel model of DenseCNN and ordered-neuron LSTM for generic and species-specific succinylation site prediction.

Lysine succinylation (Ksucc) regulates various metabolic processes, participates in vital life processes, and is involved in the occurrence and development of numerous diseases. Accurate recognition of succinylation sites can reveal underlying functional mechanisms and pathogenesis. However, most remain undetected. Moreover, a deep learning architecture focusing on generic and species-specific predictions is still lacking. Thus, we proposed a deep learning-based framework named Deep-Ksucc, combining a dense convolutional network and ordered-neuron long short-term memory in parallel, which took the cascading characteristics of sequence information and physicochemical properties as the input. The results of the generic and species-specific predictions indicated that Deep-Ksucc can identify sequence patterns of different organisms and recognize plenty of succinylation sites. The case study showed that Deep-Ksucc can serve as a reliable tool for biology verification and computer-aided recognition of succinylation sites.