Blood Lipid is Associated with Skeletal Muscle PPARδ Protein Content after a 10-week Resistance Exercise Training: 3272 Board #141 June 2 9 30 AM - 11 00 AM

Peroxisome proliferator activated receptors (PPARs) are main regulators of blood lipid profile while PPARδ is the most abundant PPARs isoform in skeletal muscle. Although skeletal muscle is a major player in lipid metabolism, the association between muscle PPARδ and blood lipid profile is currently unknown. PURPOSE: The purpose of this study was to investigate the association between muscle PPARδ protein content and blood lipid in the context of resistance exercise training. METHODS: Fifteen untrained, healthy young men (n=8) and women (n=7) performed a 10-week progressive whole-body resistance exercise training program. Muscle samples were obtained from the vastus lateralis muscles 24 hours before the first exercise and 24 hours after the last exercise. Blood samples were collected from antecubital veins immediately before the first and the last exercises. Western Blotting was conducted to quantify the PPARδ content, and serum lipid profile was analyzed. RESULTS: While PPARδ protein content was not correlated with blood lipid profile before the training, it was negatively correlated with total cholesterol (R=-0.731, R-square=0.534, P=0.04) and LDL (R=-0.746, R-square=0.557, P=0.033) after the training. CONCLUSION: The results imply that resistance exercise training may enhance the regulation of blood lipid via PPARδ.Table: No title available.