Abstract 8881: Comprehensive Assessment of Systemic Atherosclerosis in Relation to the Ocular Resistive Index in Acute Coronary Syndrome Patients

Introduction: It remains unclear how systemic atherosclerosis can affect ocular microvessels. The abnormality of the ocular microvasculatures can be non-invasively detected by measuring ocular arterial blood flow velocity using laser speckle flowgraphy (LSFG). Among the ocular blood flow parameters obtained by LFSG, the ocular blowout time (BOT) and the ocular resistivity index (RI) are used as the index of retinal vascular resistance. The purpose of this study was to investigate the relationship between ocular vascular resistance evaluated by LSFG and cardiac function evaluated by transthoracic echocardiography in patients with acute coronary syndrome (ACS). Methods: We evaluated 53 patients with ACS who were taken to Coronary Care Unit between April 2019 and September 2020. The mean blur rate (MBR), the ocular blowout time (BOT) and the ocular resistivity index (RI) were measured by LSFG. In addition, the age-matched normal subjects were also evaluated the measurement of LSFG in 20 healthy subjects with no ocular disease and no history of cardiovascular disease. Results: Among all ACS patients, there were significant positive correlations between ocular RI and systemic parameters, i.e., IMT(r = 0.34, P = 0.01), PWV(r = 0.41, P < 0.01), BUN(r = 0.27, P = 0.047), cystatin C(r = 0.32, P = 0.020), urinary β2 microglobulin(r = 0.30, P = 0.029), L-FABP(r = 0.28, P = 0.046), and E/e’(r = 0.34, P = 0.013). There was also significant negative correlation between ocular BOT and PWV(r = -0.44, P < 0.01). Age-matched comparing the selective ACS (n=20) with healthy group (n=20), the ocular RI was significantly higher in the ACS group (0.34 ± 0.04 vs 0.38 ± 0.07, P = 0.03). Conclusions: We found that the ocular resistivity index, which was non-invasively obtained by LSFG, was associated with systemic atherosclerosis, early renal dysfunction and cardiac diastolic dysfunction in ACS patients, suggesting that it might be useful index as an non-invasive comprehensive arteriosclerotic markers.