Epidemiology of pneumococcal serotypes in children with outpatient pneumonia and carriers in Krasnoyarsk

I. N. Protasova, N. A. Ilyenkova, E. S. Sokolovskaya

Pacific Medical Journal(2019)

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摘要
Objective: The objective is to analyze the seroepidemiology and resistance of Streptococcus pneumoniae in children over 5 y.o.Methods: 57 patients with pneumonia and 186 healthy children were examined. The induced sputum and nasopharyngeal swabs were analyzed with culture and molecular assays.Results: S. pneumoniae incidence among healthy children was 15.1 %. Serotype flora was represented by 4 serotypes and 6 serogroups with prevalence of 19F, 37 (for 17.8 % each), 6АВС, 3 (for 10.7 % each). 17.8 % of strains were antibiotic resistant, four of them was 19F serotype, and one was of the 6th serogroup. All of them were multiresistant: to macrolides, lincosamides, tetracyclines, cephalosporins of II generation along with moderate resistance to penicillin. In children with pneumonia, pneumococcocus was detected in 24.6 % of cases: serotypes 19F (64.3 %), 19А (21.4 %), 23F (14.3 %). 57.1 % of strains were multiresistant and was of 19F and 19А serotypes. Phenotype of the resistance was identic to the described above except the resistance to amoxicillin: all strains were resistant to it. All given isolates were moderately resistant to ceftriaxone.Conclusions: Serotype flora of pneumococci in healthy children of school age was distinct in significant variety with high incidence of ‘mucoid’ serotypes 3 and 37 (28.6 %). In pneumonia, pneumococci of 19F and 19A types occurred significantly frequently. The main resistant serotype of S. pneumoniae in both groups was 19F with lowered sensitivity to beta-lactam antibiotics.
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关键词
pneumococcal serotypes,outpatient pneumonia,epidemiology
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