The Association between LINC00511 Variants and Breast Cancer Susceptibility among the Han Chinese Population

Objective LINC00511 has been considered an oncogene for breast cancer, however, the association between LINC00511 Single nucleotide polymorphisms（SNPs） and breast cancer risk remains unclear. Methods A total of 504 breast cancer patients and 505 cancer-free controls were genotyped for 12 LINC00511 SNPs. A logistic regression analysis was conducted to explore the association between LINC00511 SNPs and breast cancer susceptibility, adjusting for reproductive factors. A haplotype analysis and interaction analysis were applied to assess the role of LINC00511 in breast cancer. Results LINC00511 SNPs were significantly correlated with breast cancer. The TT genotype of rs11657109 reduced the risk of breast cancer（OR: 0.454, 95%CI: 0.212-0.970）, while the AG and GG genotypes of rs17780195 played a protective role（OR: 0.723, 95%CI: 0.539-0.970; OR: 0.398, 95%CI: 0.184-0.860, respectively）. The mutation of rs9906859 may also lead to a reduction in breast cancer susceptibility（OR: 0.682, 95% CI: 0.520-0.894）. Furthermore, LINC00511 SNPs（rs4432291, rs1558535, rs17780195 and rs9906859） are associated with the HER-2 status（P ＜ 0.05 for all）. The interaction of rs9906859, breastfeeding and age increased the breast cancer risk by 4.318（OR: 5.318, 95%CI: 2.214-12.774）. Conclusions LINC00511 SNPs were associated with the risk of breast cancer. There was an association between LINC00511 SNPs and the HER-2 status. There were interactions between LINC00511 SNPs and reproductive factors that affected the risk of breast cancer.