Nanoscale Imaging of Chromatin with Labeled and Label-Free Super-Resolution Microscopy and Partial-Wave Spectroscopy

Adam Eshein,Yue Li, Xiang Zhou,Graham Spicer,The-Quyen Nguyen,Luay M. Almassalha,John E. Chandler,Scott Gladstein,Biqin Dong,Cheng Sun,Hao F. Zhang,Vadim Backman

Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS)（2018）

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摘要

We demonstrate a multimodal imaging system that combines partial-wave spectroscopic microscopy and spectroscopic super-resolution microscopy to study chromatin topology. This instrument allows nanoscale visualization of labeled and unlabeled chromatin with molecular and structural contrast.

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