Correction to Organic Radical Contrast Agents for Magnetic Resonance Imaging

We re-examined the T1 weighted raw data and found that the raw signal intensity scale was changing despite the designation of “absolute value” reconstruction on the Bruker scanner. There was a hidden “slope” factor that modifies the raw intensities when the absolute value reconstruction was designated. This does not affect the signal within a single acquisition, such as the T1 mapping data, but does affect the intensity scales before and after injection of contrast agent. Elimination of this scaling factor (done via user designation of the slope and offset in the reconstruction options) eliminates this factor and provides a true rendering of the signal changes with constant acquisition parameters and constant receiver gain (which was done in all experiments). Page 15726. Correction to the subtraction images and caption in Figure 3. We obtain corrected subtraction image