Renal Cell Carcinoma in People with HIV- An Analysis of the Postoperative Factors Associated with the Long-Term Survival

Aims: The purpose of the current study is to explore the prognostic factors of the renal cell carcinoma (RCC) in People living with HIV (PLWH), and to evaluate the postoperative factors associated with the survival in PLWH with RCC.Methods: PLWH with RCC who underwent surgical treatment were retrospectively studied. A single-center analysis was conducted from January 2012 to January 2021. General and postoperative clinical data, including age, gender, smoking and drink history, active antiretroviral therapy (ART), cancer histology, clinical and pathological stage, surgical result, Glasgow Prognostic Score (GPS), the Charlson comorbidity index(CCI), the Karnofsky performance status (KPS）, CD4+ T cell count, CD4/CD8 ratio and survival time were collected.Results: A total of 67 patients were included in our study. The Creatine (77.1±18.8 vs 85.7±12.9, P value=0.032), HGB(mg/dL) (113.6±12.6 vs 139.3±20.8, P value=0.694), the CD4/CD8 ratio (0.68±0.40 vs 0.86±0.33, P value=0.006) and overall survival time (months) (74.93±5.249 vs 96.47±3.28, P value=0.009), the progression free survival time (months) (66.47±6.56 vs 90.65±4.82，P value=0.011). The Cox regression analysis showed that the tumor size and the CD4/CD8 ratio were prognostic factors for survival time.Conclusion: In our retrospective analysis, the survival prognosis of negative group was better than that of PLWH with RCC. The risk factors for overall survival in PLWH with RCC was tumor size and CD4+/CD8+ ratio. The lower CD4/CD8 ratio was a significant predictive factor for shorter overall survival.