Hepatobiliary alterations in ulc a tertiary care centre in odisha

Background and Aim: manifestations in chronic ulcerative colitis patients. alterations in ulcerative colitis hepatobiliary alterations in ulcerative colitis patients admitted to a tertiary care centre in Odisha. Methods: Medical College, Cuttack from 0ct 2013 to April 2015 were included in the study. Patients with history of liver diseases were excluded. All patients were subjected to clinical examination, function tests and ultrasonography for evaluation of in selected patients. Controls were recruited from healthy subjects (n=100). patients [73(65.1 %%) male; 39(34.9%) female] with ulcerative colitis were included. The mean age and BMI wer severe disease activity were 22(19.6%), 67(59.8%) and 23(20.5%) respectively. The median duration of illness was 24 months (IQR:6.5 patients(60.7%).40(35.7%) patients had arthralgia, episcleritis,2(1.7%) had stomatitis, 3(2.6%) had Erythematic Nodosum, 1(0.9%) had pyoderma Gangrenosum. 60 (53.8%) patients developed hepatobiliary alterati and clay colored stool in whom MRCP revealed primary sclerosing cholangitis. 22(19.6%) had hepatic steatosis, 42(37.5%) had asymptomatic transaminitis, 17(15.1%) had elevated alkaline phosphatase and 67(60%) had hypoalbum 28(28%) had transaminitis, 8(8%) had elevated alkaline phosphatase. that approximately 61% of Ulcerative colitis patients had extra intestinal manifestations. Hepatobiliar alterations are the most common (53.5%) extra intestinal manifestations in Ulcerative colitis and asymptomatic transaminitis is the most common hepatobiliary alterations in the patients with Ulcerative colitis in the present study.