Prognostic value of Ki-67 and prediction in patients with hypertension and prostate cancer: A Real-World Study of Chinese Group for Prostate Cancer Party

Purpose Prostate cancer is the second most common malignancy with high mortality among males around the world, especially combine with hypertension. Ki-67 is one of the most reliable markers for growth fraction of neoplastic human cell populations. However, the prognostic value and prediction of Ki-67 in patients with hypertension and prostate cancer remain unclear. Materials and methods We launched a retrospective analysis of 296 patients with hypertension and prostate cancer from May 1, 2012, to Oct 1, 2015. The overall survival was evaluated using Cox regression models and Kaplan-Meier analysis. A nomogram was established. The accuracy of the model was assessed by calibration curve. Results Multivariate analysis showed that the Ki-67 (+) class was associated with an over 5-fold increase in the risk of death (HR 5.83, 95% CI 3.35-10.14, p<0.001) and a 2-fold increase in the risk of progression (HR 2.06, 95% CI 1.37-3.10, p<0.001). Multivariate Lasso regression showed that smoking, heart failure, ACS, Ki-67 expression, serum albumin, prognostic nutritional index, surgery, Gealson score, and stage were positively associated with prognosis in patients with prostate cancer. To quantify the contribution of each covariate to the prognosis, a nomogram of the Cox model was generated and displayed. The nomogram demonstrated excellent accuracy in estimating the risk of death, with a bootstrap-corrected C index of 0.829. There was also a suitable calibration curve for risk estimation.Conclusions Ki-67(+) predicts worsened outcomes of OM. A cross-validated multivariate score, including Ki-67(+), showed excellent concordance and efficacy of predicting prostate cancer.