Molecular Rearrangement of Pyrazino[2,3-c]quinolin-5(6H)-ones during Their Reaction with Isocyanic Acid.

Antonín Klásek,Antonín Lyčka,Filip Křemen,Aleš Růžička,Michal Rouchal

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES（2022）

引用 0|浏览2

暂无评分

摘要

New tetrahydropyrazino[2,3-c]quinolin-5(6H)-ones were prepared from 3-chloroquinoline-2,4(1H,3H)-diones and ethylene diamine. In their reaction with HNCO, an unprecedented molecular rearrangement produced new types of hydantoin derivatives. All prepared compounds were characterized on the basis of their 1H, 13C, and 15N NMR and ESI mass spectra and some were authenticated by X-ray analysis of single crystalline material. A proposed mechanism for rearrangement is discussed in this essay. The CDK and ABL inhibition activity as well as in vitro cytotoxicity of the prepared compounds was also tested.

查看译文

关键词

3-(3-acylureido)-2, 3-dihydro-1H-indol-2-ones, 4-alkylidene-1'H-spiro[imidazolidine-5, 3'-indole]-2, 2'-diones, imidazo[1, 5-c]quinazoline-3, 5-diones, H-1-, C-13- and N-15-NMR, scXRD, biological activity

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要