Abstracts for the 2019 Scandinavian Society of Anaesthesiology and Intensive Care Medicine Congress in Copenhagen

Abstracts for the 2019 Scandinavian Society of Anaesthesiology and Intensive Care Medicine Congress in Copenhagens for the 2019 Scandinavian Society of Anaesthesiology and Intensive Care Medicine Congress in Copenhagen ACTA COMPETITION (5 ABSTRACTS) ABSSUB125 | Does nonsedation affect quality of life following critical illness? Hanne T. Olsen1,2,*; Helene K. Nedergaard1,3; Hanne I. Jensen3,4; Thomas Strøm5; Palle Toft1,5 1Department of Clinical Research, University of Southern Denmark, Odense, 2Department of anesthesiology and intensive care, Odense University Hospital, Svendborg, 3Department of anesthesiology and intensive care, Lillebaelt Hospital, Kolding, Kolding, 4Department of Regional Health Research, University of Southern Denmark, 5Department of anesthesiology and intensive care, Odense University Hospital, Odense, Denmark Background: Critical illness can severely impair healthrelated quality of life (HRQL) for years following discharge. The NONSEDAtrial was a Scandinavian multicenter randomised trial in critically ill, mechanically ventilated patients, with eight participating Intensive Care Units (ICU). The main aim was to assess if nonsedation vs sedation with a daily wakeup trial improved survival. The aim of this substudy was to assess the effect of nonsedation on HRQL. Method: Patients participating in the NONSEDAtrial were randomised to nonsedation or sedation within the first 24 hours of mechanical ventilation. Nonsedated patients received no sedatives; sedated patients received propofol (first 2 days) and then midazolam. Bolus doses of morphine were used in both groups for pain and discomfort. All survivors from the NONSEDAtrial were asked to complete the Medical Outcomes Study ShortForm 36 questionnaire (SF36) 3 months post ICUdischarge. SF36 is validated within critical care. To limit missing data, reminders were sent by mail. If unsuccessful, telephone interviews could be used. Outcomes were assessed blinded. Results: In total, 700 patients were included between 2014 and 2017, and 412 survived to followup. A total of 339 survivors participated (82%). Baseline data were equal between nonsedated (n = 167) and sedated (n = 172) patients, with regard to age (median 72.5 vs 70.0 years), APACHEIIscore (median 26 vs 25) and gender (36% females vs 42%). Mean SF36 scores for the nonsedated vs sedated patients were: Physical Function 50 vs 40, P = .22, Bodily Pain: 53 vs 56, P = .55, General Health: 52 vs 50, P = .22, Vitality: 44 vs 38, P = .32, Social Function: 75 vs 63, P = .18, Role Emotional: 58 vs 50, P = .50, Mental Health: 75 vs 70, P = .40, Role Physical: 31 vs 25, P = .11. Conclusion: Nonsedation had no significant effect on HRQL 3 months post ICUdischarge, although nonsedated patients scored better within seven of the eight SF36 domains. Disclosure of Interest: None Declared.