Advancing strategies to increase adherence to oral therapies in onco-hematology: a randomized study (Preprint)

BACKGROUND The use of oral treatments is constantly growing in the area of onco-hematology, raising adherence and safety issues. There is an increasing body of literature highlighting the importance of patient empowerment in the self-management of cancer therapies. Within this scenario, the ONCO-TreC platform was customized and fine-tuned through a prospective multicenter training-validation study in cancer patients treated with oral anticancer drugs. OBJECTIVE This prospective randomized trial was designed to compare the effectiveness of two different strategies, ie, an electronic diary (ONCO-TreC) and a paper diary, for the management of oral cancer treatments in patients with solid and hematological tumors. METHODS Ad hoc strategies are planned to measure and monitor adherence to treatment and to assess usability and acceptability of the electronic diary. Informed consent will be obtained from all study participants. RESULTS This innovative eHealth system is expected to contribute to increasing the adherence to and safety of cancer care, promoting patient empowerment and improving patient-doctor communication. Ethical approval was obtained from the Independent Ethics Committees of the participating institutions (CEIIAV protocol no. 2982/2020; reference no. 2108). CONCLUSIONS Findings will be disseminated through peer-reviewed journals, conferences and event presentations. CLINICALTRIAL ClinicalTrials.gov NCT04826458; Institutional ID no. IRST100.28