Correlation between the Concentration of DNA and Electrical Bioimpedance

Biosensors have recently been used for the identification and genetic characterization of diseases such as Salmonella, human papilloma, and breast cancer. The aim of this study was to examine the relationship between different concentrations of Deoxyribonucleic Acid (DNA) and the corresponding values of magnitude and phase of Electrical Bioimpedance (EBI). Functions that characterize the correlation of DNA with these two parameters were derived from linear regression by means of the least squares method. According to the results, it is feasible to determine the concentration of DNA from EBI measurements (at a specific frequency) of magnitude and phase, taking into account the corresponding linear functions. The present findings indicate the feasibility of using EBI measurements of magnitude and phase as a biosensor for the detection of genes associated with genetic and infectious diseases.