Mapping Myeloma: A Roadmap of Daratumumab Use in Clinical Pathways

Background: While myeloma remains an incurable disease, novel therapies have significantly improved survival. Daratumumab is a human IgG1κ anti-CD-38 monoclonal antibody that is approved in several different combinations in the first line and relapsed refractory setting (Daratumumab. Package insert. Janssen Biotech, Inc.; 2021.). However, there is little guidance on treatment selection and sequencing. Clinical pathways have been implemented at different institutions as a decision support tool for the treatment of complex diseases. Dana-Farber Cancer Institute (DFCI) Clinical Pathways includes daratumumab based regimens in 11 of 15 nodes for myeloma treatment.