Characterization of Medical Conditions of Children with Sickle Cell Disease in the United States: Findings from the 2007-2018 National Health Interview Surveys (NHIS)

Background: Sickle cell disease (SCD), one of the most common genetic disorders in the United States (US), affects 70,000 to 100,000 children. The burden is greatest among the African American population, where SCD impacts 1 in 365 live births. Children with SCD have been observed to have lower Health-Related Quality of life (HRQoL) due to the impact of severe disease-related complications and comorbidities, including infections, pain crises, acute chest syndrome, metabolic alterations and overt stroke. SCD and its related comorbidity and complications result in increased health care utilization, particularly emergency department use- which accounts for 80% of medical expenditure. Further, studies using US population-based data to characterize the health status and health care utilization for SCD children is lacking. With the exception of a study conducted by Boulet et al. in 2010, which examined the 1997-2005 National Health Interview Surveys (NHIS) data to describe health status and health services use among Black children aged 0-17 years with SCD. To fill this important gap, we used the 2007-2018 NHIS data to describe health status and health services use among SCD children aged 0-17 years and conducted a sub-analysis for Black children to better characterize SCD- related medical conditions affecting this population and health care utilization patterns.