Evaluation Of Different Serum Uric Acid Levels On The Prognosis Of Patients With St-Segment Elevation Myocardial Infarction After Emergency Percutaneous Coronary Intervention

Objective: To explore the implication of different serum uric acid (UA) levels on the prognosis in patients with ST-segment elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI). Methods: A prospective study was conducted on 290 patients with STEMI who underwent PCI and were combined with hyperuricemia. According to high and low control levels of serum UA at initial diagnosis, they were divided into a low-level group with 85 cases, a medium-level group with 105 cases, and a high-level group with 100 cases. The status of coronary angiography and neutrophil/lymphocyte ratio (NLR) in the different groups were compared. The linear correlation between UA and NLR was analyzed by Pearson correlation analysis. The left ventricular function at 3 months after operation and the incidence of adverse events in the 5-year of follow-up visit were determined. Results: There was a statistical difference in the proportion of triple-vessel lesion among three groups (P < 0.05), and the incidence of triple-vessel lesion in the high-level group was higher than that in the low-level and mediumlevel groups (all P < 0.05). There was a statistical difference in the NLR level of the three groups (P < 0.05), and the NLR level in the high-level group was higher than that in the low-level and medium-level groups (all P < 0.05). The UA level was positively correlated with the peripheral blood NLR (r = 0.325, P < 0.001). After treatment, the left ventricular ejection fraction (LVEF) of patients in the high-level group was lower than that in the low-level and medium-level groups (all P < 0.05), while the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD) and left atrial diastolic diameter (LADD) were higher than those in the low-level and medium-level groups (all P < 0.05). The number of cases with heart failure and cerebrovascular events in the high-level group were more than those in the low-level group, and the total incidence of adverse events in the high-level group was higher than that in the low-level and medium-level groups (all P < 0.05). Conclusion: The elevated serum UA level is correlated with the occurrence of hypertension, the elevated NLR level and the decreased left ventricular function. The elevated serum UA level increases the incidence of adverse events after emergency PCI in patients with STEMI.