Considering Solubility Disparity And Acoustic-Cavitation Susceptivity Of Neoteric Solvents To Accurately Predict Sono-Recovery Yield Of Value-Added Compounds

This work aimed to theoretically predict the sono-recovery yield of value-added compounds in various neoteric solvents through considering solubility difference and acoustic-cavitation variability. Preferentially, the solventsolute compatibility was calculated by Hansen solubility parameters (HSPs), but unexpectedly the results showed that the HSPs prediction was not preferably consistent with the tendency of extraction yield. Subsequently, calculated correlations between maximum bubble radius (MBR) and solvent properties showed the following hierarchies: viscosity (-0.86**) > density (-0.83**) > surface tension (-0.64**), and MBR can be considered as a mirror of solvent properties to reflect the flavonoids yield (r = 0.75**) but that was inapplicable to phenolic acids (r = 0.33). Evidentially, micromorphological observation exhibited that significant modification of epidermis had an intense disposition to occur in the solvents with greater MBR such as methanol, water and ethyl acetate. No significant sonochemiluminescence (SCL) signal was captured including aqueous malic acid/choline chloride (ChCl), lactic acid/ChCl, sucrose/ChCl, methanol, ethyl lactate, and glycerol, but the addition of ChCl into alcohols can enhance the production of free radicals. The generation of free radicals was independent of MBR and their impacts on final compounds presented pluralist and limited effects. In addition, how to more accurately quantify the effects of free radicals on the final compounds is still a poser. Overall, This work constructed a bridge between theoretical calculation and laboratory data and demonstrated the fundamentality of maximum bubble radius in the biorefinery of value-added compounds.