Hysterectomy-Corrected Mortality Rates Of Corpus Uteri Cancer In Denmark During 2002-2015

Introduction/Background Corpus uteri cancer is the most common gynaecological malignancy in Denmark. Whereas the incidence of less aggressive histologic subtypes (i.e. endometrioid cancer) has been stable since 2000, the incidence of more aggressive subtypes (i.e. non-endometrioid cancer) has been reported to increase in Denmark. It is important to assess whether this trend may be reflected in an increased mortality rate. Here, we aimed to describe hysterectomy-corrected mortality rates of corpus uteri cancer, overall and stratified by age and histologic subtype. Methodology Using data from nationwide registries, we calculated uncorrected and hysterectomy-corrected age-standardized mortality rates of corpus uteri cancer among women aged 35 years and older during 2002–2015. Individual-level hysterectomy status was obtained from the Danish National Patient Registry; hysterectomy-corrected mortality rates were calculated by subtracting post-hysterectomy person-years from the denominator, unless hysterectomy was performed due to corpus uteri cancer. Results During 2002–2015, the age-standardized hysterectomy-corrected mortality rate of corpus uteri cancer was 25.5% higher than the corresponding uncorrected rate (12.3/100,000 vs. 9.8/100,000 person-years). Hysterectomy-corrected rates increased with age, reaching 43.2/100,000 person-years in women aged 70 years and older. Among all women, rates decreased from 2002 (14.0/100,000 person-years) until 2009 after which they stabilized at about 11.5/100,000 person-years, This decrease was mainly due to a decline in women aged 70 years and older. Of note, the hysterectomy-corrected mortality rate of endometrioid cancer declined slightly during the study period, from 5.8/100,000 to 4.2/100,000 person-years, whereas the mortality rate of non-endometrioid cancer increased, from 1.4/100,000 to 3.7/100,000 person-years. Conclusion Among all women, the mortality rate declined over calendar time and increased with age. While the mortality of less aggressive histologic subtypes declined, although incidence rates were stable in this time period, the mortality of more aggressive histologic subtypes paralleled the incline in the incidence of these subtypes. Disclosure The Danish Cancer Society funded this study. All authors have nothing to disclose.