Wireless Optoelectronic Fiber Photometry Headstage for Deep Brain Structures Monitoring
2018 IEEE Life Sciences Conference (LSC)(2018)
摘要
This paper presents an optoelectronic neuroscience platform for monitoring neural dynamics in intact deep brain structures. A wireless optoelectronic headstage incorporating all aspects of a conventional benchtop high-performance optical fiber photometry system is presented to detect fluorescence signal fluctuations in the brain of live animal models. The headstage includes a photosensor, a fiber optic-cannula, an excitation light source, a few passive optical components, a microcontroller, a LED driver, and a wireless transceiver. All components are enclosed within a compact and light weight 3D-printed plastic housing. The performance of the headstage was validated in-vitro with a mouse brain slice expressing GCaMP6, a genetically encoded fluorescence indicator. The proposed headstage presents a sensitivity of 50 fA over a bandwidth of 30 Hz with an excitation light power of 50 μW. The total power consumption of the headstage is approximately equal to 600 mW. The headstage prototype results in a lightweight ( 3.6 ≤, w/o battery) and compact device (22 × 8 × 17 mm
2
) which is mountable on the head of a small animal model.
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关键词
Optoelectronic headstage,Fluorescence,Photodetector,Fiber photometry,Transimpedance amplifier,Wireless
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