Metabolic Markers And Circulating Adipokines Profiles In Normal Versus Overweight And Obese Aged Women With Different Physical Activity

PURPOSE: The goal of this study was to investigate the metabolic markers and circulating adipokine profiles in normal versus overweight and obese aged women with different physical activity. METHODS: A total of 104 women, aged 50-77 years, were included in this cross-sectional study. Body composition was measured by the DXA (GE Lunar Prodigy, USA). Serum circulating adipokines and lipid and glucose metabolism makers’ levels were determined by radioimmunoassay. Waist-mounted triaxial accelerometer Actigraph GT3X-BT was used to make objective 7-day recordings of physical activity. Based on the mean of the minutes spent in moderate to vigorous physical activity (180 min/week) and BMI, subjects were divided into four groups: Normal Low MVPA group (n = 13), Normal High MVPA group (n = 18), Obese Low MVPA group (n = 34) and Obese High MVPA group (n = 39). RESULTS: All metabolic markers (HOMA-IR, insulin, triglyceride, PBF) and circulating leptin were higher in Obesity than Normal group (all p < 0.01), adiponectin level was lower in Obesity than Normal group (18.5 ± 13.2 VS 28.1 ± 13.1 μg/ml; p < 0.01). Level of HOMA-IR, insulin, triglyceride and serum leptin and adiponectin were similar between NL and NH, OL and OH (all p > 0.05). However, PBF of OH was lower than OL group significantly (37.9 ± 4.6 VS 40.6 ± 4.7%; p < 0.01). All metabolic markers and serum leptin were higher in OH than NL group (1.75 ± 0.98 VS 1.08 ± 0.55;7.5 ± 3.5 VS 4.9 ± 2.6μU/ml; 1.44 ± 0.66 VS 1.06 ± 0.37 mmol/L; 37.9 ± 4.6 VS 30.8 ± 3.6%;10.9 ± 7.1 VS 5.1 ± 4.1 ng/ml; all p < 0.05), adiponectin level was lower in OH than NL group (16.2 ± 11.1 VS 27.3 ± 13.2 μg/ml; p < 0.01); Levels of HOMA-IR, insulin, PBF were higher in OL than NH (2.24 ± 1.53 VS 0.97 ± 0.23; 8.9 ± 0.23 VS 4.6 ± 1.1μU/ml; 40.6 ± 4.7 VS 31.7 ± 4.2%; all p < 0.01), however, leptin and adiponectin levels were not found significant differences in OL and NH group(both p > 0.05). CONCLUSIONS: Leptin and adiponectin might play a role in protecting against obesity-associated cardiometabolic derangements. The level of circulating adipokines and body composition might be moderated by physical activity. Further research is thus required to clarify the clinical significance of such findings. This work was supported by Beijing Municipal Education Commission(Grants No.SM202110051003).