Calcium channels in the development, maturation, and function of spermatozoa.

Darszon A, Nishigaki T, Beltran C, Trevino CL. Calcium Channels in the Development, Maturation, and Function of Spermatozoa. Physiol Rev 91: 1305-1355, 2011; doi: 10.1152/physrev.00028.2010.-A proper dialogue between spermatozoa and the egg is essential for conception of a new individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event leading to a new life. No wonder that nature has devised different Ca2+-permeable channels and located them at distinct sites in spermatozoa so that they can help fertilize the egg. New tools to study sperm ionic currents, and image intracellular Ca2+ with better spatial and temporal resolution even in swimming spermatozoa, are revealing how sperm ion channels participate in fertilization. This review critically examines the involvement of Ca2+ channels in multiple signaling processes needed for spermatozoa to mature, travel towards the egg, and fertilize it. Remarkably, these tiny specialized cells can express exclusive channels like CatSper for Ca2+ and SLO3 for K+, which are attractive targets for contraception and for the discovery of novel signaling complexes. Learning more about fertilization is a matter of capital importance; societies face growing pressure to counteract rising male infertility rates, provide safe male gamete-based contraceptives, and preserve biodiversity through improved captive breeding and assisted conception initiatives.