Corrigendum to “International Tailored Chemotherapy Adjuvant (ITACA) trial, a phase III multicenter randomized trial comparing adjuvant pharmacogenomic-driven chemotherapy versus standard adjuvant chemotherapy in completely resected stage II-IIIA non-small-cell lung cancer”: [Annals of Oncology 33 (2022) 57-66]

S Novello, V Torri,C Grohe,S Kurz, M Serke, T Wehler,A Meyer, D Ladage, M Geissler, I Colantonio, C Cauchi, E Stoelben, A Ceribelli, C Kropf-Sanchen, G Valmadre, G Borra,M Schena, A Morabito,A Santo,V Gregorc,R Chiari,M Reck, G Schmid-Bindert,G Folprecht, F Griesinger, A Follador, P Pedrazzoli,A Bearz, O Caffo,N J Dickgreber, L Irtelli, G Wiest,V Monica,L Porcu, C Manegold,G V Scagliotti

Annals of Oncology(2022)

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摘要
•Adjuvant platinum-based chemotherapy is accepted as standard of care in stage II and III (NSCLC) patients.•Several studies addressed the question of whether molecular tumor markers may serve as predictive biomarkers.•ITACA was planned to evaluate the predictive utility of ERCC1 and TS mRNA expression levels in completely resected NSCLC.•ITACA results indicate that adjuvant chemotherapy customization based on ERCC1 and TS mRNA levels did not improve efficacy.•In terms of safety, the pharmacogenomic-driven arm was associated with better efficacy/toxicity ratio.
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关键词
non-small-cell lung cancer,adjuvant chemotherapy,pharmacogenomics,excision repair cross-complementation 1,thymidylate synthase,messenger RNA
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