Inter Trial Coherence Of Low-Frequency Oscillations In The Course Of Stroke Recovery

Objective: The aim was to find a sensitive method to highlight the remodeling of the brain's bioelectric activity in post-stroke repair. Methods: Fifteen mild upper limb paretic stroke patients and age-matched healthy controls were included. Repeated trials of finger tapping around the 10th and 100th days after stroke onset were recorded with a 128-channel EEG. Power spectra and Inter Trial Coherence (ITC) calculations were synchronized to tappings. ITC was correlated with motor performance. Results: ITC, in low frequency bands, designates the motor related bioelectric activity in channel space in both healthy subjects and patients. Ten days after stroke onset, delta-theta ITC was severely reduced compared to baseline, while three months later ITC reorganized partially over the ipsilesional central parietal areas reflecting the improvement of motor networks. Decreased ITC in the central-parietal area remained significant compared to controls. Delta band ITC over the dorsolateral-prefrontal cortex correlates with the performance on Nine Hole Peg Test. At post-recovery, non-paretic hand tappings show significantly decreased delta-theta ITC over the supplementary motor area, which reflects network remodeling. Conclusions: Inter Trial Coherence is a useful measure of brain reorganization during stroke recovery. Significance: Delta-theta ITC is a sensitive indicator of impaired motor execution. (c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.