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Fecal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) RNA Is Associated With Decreased Coronavirus Disease 2019 (COVID-19) Survival

Upasana Das Adhikari,George Eng,Mara Farcasanu,Laura E Avena,Manish C Choudhary,Virginia A Triant,Meaghan Flagg,Abigail E Schiff, Isabella Gomez,Leah M Froehle,Thomas J Diefenbach,Larance Ronsard,Daniel Lingwood,Grace C Lee,Seyed Alireza Rabi,Derek Erstad,George Velmahos,Jonathan Z Li,Richard Hodin,James R Stone,Anna N Honko,Anthony Griffiths,Ömer H Yilmaz,Douglas S Kwon

CLINICAL INFECTIOUS DISEASES（2022）

Cited 13|Views25
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Abstract
The clinical significance of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) RNA in stool remains uncertain. We found that extrapulmonary dissemination of infection to the gastrointestinal tract, assessed by the presence of SARS-CoV-2 RNA in stool, is associated with decreased coronavirus disease 2019 (COVID-19) survival. Measurement of SARS-CoV-2 RNA in stool may have utility for clinical risk assessment.
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SARS CoV-2, mortality, fecal, RNA, organoids, GI epithelium, phylogenetics
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