Regenerative approach to the treatment of covid-19 patients

The prescription or over the counter pharmaceutical drugs taken by the patients are not devoid of adverse effects that can outweigh the benefit of a drug As compared to the mainstream treatment using synthetic or natural drugs, cellular medicine is the newest entry to clinical practice and it is primarily considered as experimental treatment till date It relies on the technology on replacing diseased or dysfunctional cells with functional healthy cells leading to healing/repair and rejuvenation Its use as pharmaceutical intervention is of utmost importance primarily due to the emerging evidence on its key roles in regulating the inflammatory balance, inflammaging, and several other key biochemical mechanisms such as mitochondrial dysfunction (MD), endoplasmic reticulum (ER) and Golgi stress that play important roles in the initiation and the progression of many infectious diseases The outbreak of novel coronavirus (SARS-CoV-2) (COVID-19) has been a major cause of public health concern around the world since the beginning of the pandemic in early 2020 The mesenchymal stem cells (MSCs) have immunomodulatory properties Although, the exact mechanism of actions have not been fully understood, it is believed MSCs have the ability to effectively regulate the inflammatory balance to ameliorate infectious diseases Furthermore, it is also proposed MSCs can suppress the inflammasome which is a key target in many immune-related disorders Additionally, the beneficial roles of MSCs in ameliorating ER stress and MD have been observed in many other diseases Taken together, many of the underlying mechanisms that play significant roles in the progression of COVID-19 infection in individuals can be modulated by MSCs Thus, MSCs may ameliorate the severity of disease symptoms in COVID-19 patients with fewer side effects and reduced cost as compared to pharmaceutical drugs © Nova Science Publishers, Inc