Anxiety, Depression, And Glycemic Control During Covid-19 Pandemic In Youths With Type 1 Diabetes

Objectives: Our study aims to assess the impact of lockdown during the coronavirus disease 2019 pandemic on glycemic control and psychological well-being in youths with type 1 diabetes.Methods: We compared glycemic metrics during lockdown with the same period of 2019. The psychological impact was evaluated with the Test of Anxiety and Depression.Results: We analyzed metrics of 117 adolescents (87% on Multiple Daily Injections and 100% were flash glucose monitoring/continuous glucose monitoring users). During the lockdown, we observed an increase of the percentage of time in range (TIR) (p<0.001), with a significant reduction of time in moderate (p=0.002), and severe hypoglycemia (p=0.001), as well as the percentage of time in hyperglycemia (p<0.001). Glucose variability did not differ (p=0.863). The glucose management indicator was lower (p=0.001). 7% of youths reached the threshold-score (>= 115) for anxiety and 16% for depression. A higher score was associated with lower TIR [p= O. 028, p= 0. 012].Conclusions: Glycemic control improved during the first lockdown period with respect to the previous year. Symp- toms of depression and anxiety were associated with worse glycemic control; future researches are necessary to establish if this improvement is transient and if psycho- logical difficulties will increase during the prolonged pandemic situation.