Y Association Between The Difference Of Bilateral Brachial-Ankle Pulse Wave And Cardiovascular Events, All-Cause Mortality

Aims: To assess whether an elevated bilateral pulse wave velocity difference (BPWVD) is associated with a higher risk of cardiovascular disease (CVD) and allcause mortality. Methods and Results: We included 38512 participants from the community-based longitudinal Kailuan Cohort. These participants underwent measurements of the brachial-ankle pulse wave velocity (baPWV) from 2010 to 2011, and were followed to 2018 for CVD outcome and to 2019 for mortality. During a mean followup of 4.30 years of CVD and 5.23 years of all -cause mortality, 815 CVD cases (cerebral infarction, n = 556; intracerebral hemorrhage, n = 70; myocardial infarction, n = 179) and 952 mortalities were identifi ed. The mean BPWVD was 63.0?8.8 cm/s (median:43 cm/s; inter-quartile range:19,80 cm/s), and 9,708 (25.2%) participants were categorized as the high BPWVD group with a BPWVD in the highest quartile (≥80 cm/s). In the multivariable Cox proportional hazard model, compared with the normal BPWVD group, the high BPWVD group had a signifi cantly higher risk of myocardial infarction and all-cause mortality, with adjusted HRs (95%CI) 1.43 (95% CI: 1.04–1.96) and 1.18 (95%CI: 1.03–1.35), respectively. A higher BPWVD by one standard deviation was associated with HRs of 1.06 (95% CI: 1.02–1.10) for incident CVD, 1.10 (95% CI: 1.02–1.17) for incident myocardial infarction and of 1.07 (95% CI: 1.04–1.10) for all-cause mortality. Conclusion: Higher BPWVD was positively associated with the risks of CVD and all-cause mortality. Our fi ndings emphasize the importance of assessing BPWVD to identify high-risk individuals for CVD and mortality.