Impact Of A Pharmacist-Led Antimicrobial Stewardship Program On The Number Of Days Of Antimicrobial Therapy For Uncomplicated Gram-Negative Bacteremia In A Community Hospital

IntroductionThe need for pharmacist-led antimicrobial stewardship programs (ASP) is increasing.ObjectiveWe performed a retrospective study to assess whether pharmacist-led ASPs can decrease the duration of treatment for uncomplicated gram-negative bacteremia among patients admitted in a community hospital.MethodsThis research was conducted at a 325-bed regional general hospital in Japan, from January 2013 to June 2015. There are no infectious diseases specialists affiliated with the hospital. The outcomes of the pharmacist-led ASP group, who received pharmacist intervention, and the control group, who did not receive pharmacist intervention, were compared. The study included patients aged 18 years or older who were diagnosed with gram-negative bacteremia. The pharmacist performed an antimicrobial time-out at 72 hours after blood culture collection and optimized treatment based on the patient's clinical response and test results. The primary outcome was the duration of antibiotic treatment.ResultsIn total, 34 patients in the pharmacist-led ASP group and 32 in the control group were included in the final analysis. The median number of days of antimicrobial treatment was 8 (interquartile range [IQR]: 7-14) days in the pharmacist-led ASP group and 14 (IQR: 10-15) days in the control group. The number of days of antimicrobial treatment significantly reduced in the pharmacist-led ASP group (p < 0.001). The deescalation rates were 11 (32.4%) cases in the pharmacist-led ASP group and 4 (12.5%) cases in the control group. Hence, the trend was higher in the pharmacist-led ASP group than in the control group (p = 0.08).ConclusionThe pharmacist-led ASP reduced the number of days of antimicrobial therapy for uncomplicated gramnegative bacteremia among patients admitted in a community hospital without an infectious diseases specialist.