Pd(ii)-Catalyzed asymmetric intramolecular arylation of unbiased methylene C(sp3)–H bonds using readily accessible 3,3′-F2-BINOL as a chiral ligand
Organic chemistry frontiers(2021)
摘要
Herein, we report a Pd(ii)-catalyzed asymmetric intramolecular arylation of unbiased methylene C(sp(3))-H bonds using 2-pyridylisopropyl (PIP) as a directing group and readily accessible 3,3 '-F-2-BINOL as a chiral ligand. The reaction provided a straightforward and efficient strategy to access various chiral benzo-fused six-membered heterocyclic compounds with excellent yields (up to 99%) and enantioselectivities (up to 97%). The PIP directing group could be removed under mild conditions without the loss of enantiopurity.
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