Fe(Ii)-Driven Self-Assembly Of Enzyme-Like Coordination Polymer Nanoparticles For Cascade Catalysis And Wound Disinfection Applications

The intelligent regulation of reactive oxygen species by nanozymes and the corresponding cascade catalysis hold great potential as a promising next-generation therapeutic methodology. However, the preparation of nanozymes usually involves high material consumption and tedious multistep processes, especially during the packaging of several functional components to realize the enzyme cascade. Here, we propose a facile strategy to prepare the coordination polymer nanoparticles (CPNs) using ferrous ions as the iron source and guanosine monophosphate (GMP) as the supramolecular motif. The resultant Fe-GMP CPNs show excellent peroxidase-like activity via the conversion of H2O2 into highly active center dot OH, accompanied by high antibacterial efficiency, as well as high encapsulation capacity to simultaneously immobilize guest components through an adaptive self-assembly process. Typically, glucose oxidase (GOX) encapsulation endows as-prepared GOX@Fe-GMP CPNs with glucose-responsive properties, so that glucose can be ultimately converted into center dot OH via intermediate H2O2. This convenient cascade catalysis system not only possesses excellent antibacterial efficiencies, inhibiting the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by 99% and significantly promoting wound healing in the absence of additional H2O2, but also has great application potential in the fields of biocatalysis and biomedicine.