Quantitative gadolinium chelate-enhanced magnetic resonance imaging of normal endothelial barrier disruption from nanoparticle biophilicity interactions

The biocompatibility of macromolecular therapeutics for enhanced passive permeation and retention remains a concern due to release kinetics or surface area properties. Dendritic conjugates functionalized with paramagnetic metal chelate with diameters less than (<) 12 nm and within the 8 to 10 nm size range can be utilized for high-resolution Gadolinium-based r1−1-adjusted dynamic magnetic resonance concentration mapping of solid tumor barrier hyper-permeability and study of contrast agent pharmacodynamics. Cationic dye- or doxorubicin-linked dendrimer nanoparticle surface-to-membrane channel or receptor biophilicity interaction results in abnormal contrast enhancement of endothelial barriers identifiable by transvenous dual flip angle T1-weighted blood–brain barrier imaging with higher-generation polyamidoamine interior core gadopentetic acid-chelated dendrimers with 1 + IS 1 + functionalized exteriors. The neutralization of nanoparticle exterior surface charge would afford biocompatibility in clinical transability across abnormal barrier endothelium pores for effective transvascular delivery.