Fructose derived oligosaccharides prevent lipid membrane destabilization and DNA conformational alterations during vacuum-drying of Lactobacillus delbrueckii subsp. bulgaricus

•DNA and membrane damage led to a poor bacterial recovery after vacuum-drying.•Multicurve resolution allowed identifying damage biomarkers on vacuum-dried cells.•FOS and sucrose avoided membrane disorganization in vacuum-dried bacteria.•FOS and sucrose prevented changes on DNA native conformation in vacuum-dried bacteria.