Influence Of Posterior Tibial Slope On Three-Dimensional Femorotibial Alignment Under Weight-Bearing Conditions In Healthy Japanese Elderly People

BACKGROUND: Assessment of three-dimensional (3D) femorotibial alignment is essential for successful knee osteoarthritis treatment in the elderly. The complex morphology of the posterior tibial slope (PTS) might have an influence on sagittal and rotational alignment and the positional relationship between the femur and tibia in the anterior-posterior (AP) direction under weight-bearing conditions.OBJECTIVE: This study aimed to clarify the association between the PTS and 3D femorotibial alignment under weight-bearing conditions in healthy Japanese elderly individuals.METHODS: We investigated the 3D femorotibial alignment of 110 lower extremities of 55 healthy individuals (26 women, 29 men, mean age: 70 +/- 6 years). Using our previously reported 3D-to-2D image registration technique, we evaluated the 3D hipknee-ankle angle (3DHKA) in the sagittal plane, rotational alignment, and the distance between the femoral and tibial origins in the AP direction (tibial AP position) as femorotibial alignment parameters under weight-bearing conditions. We assessed the medial and lateral PTS and their angular difference (PTS difference) as PTS parameters. Stepwise multiple linear regression analysis was performed using PTS parameters and other possible confounders (age, sex, height, and weight) as the independent variables and femorotibial alignment parameters as the dependent variable.RESULTS: Weight (beta = 0.393, p < 0.001) and lateral PTS (beta = 0.298, p < 0.001) were the predictors associated with 3DHKA in the sagittal plane. Lateral PTS (beta = 0.304, p = 0.001) was the only predictor associated with the tibial AP position. Sex (beta = -0.282, p = 0.002) and PTS difference (beta = -0.231, p = 0.012) were associated with rotational alignment.CONCLUSIONS: We found that a steeper lateral PTS resulted in a more flexed knee and anterior tibia. The PTS difference was positively correlated with tibial external rotation. Our data could be used as the standard reference for realignment surgery to ensure PTS is appropriately maintained.