Ingenious Fabrication Of Metal-Organic Framework/Graphene Oxide Composites As Aptasensors With Superior Electrochemical Recognition Capability

The expansion and fabrication of available metal-organic framework (MOF)/graphene oxide (GO) composites is of great importance because of their expectedly splendid properties and extensive applications. In this work, MOF/GO composites are ingeniously fabricated via monolayer dispersed UiO-66-NH2 on the surface of GO. The obtained composites possess various merits from UiO-66-NH2 and GO to immensely enhance the electrochemical recognition capability, which is mainly ascribed to the strong affinity between the phosphate terminal of the aptamer and the Zr-6 cluster of UiO-66-NH2, and to the presence of pi-pi stacking force between the heterocyclic ring of the aptamer and GO. With adenosine triphosphate (ATP) as analyte, the fabricated UiO-66-NH2/GO-based aptasensor has the limit of detection (LOD) of 1.69 fg mL(-1) (3.33 fM) in a wide concentration range of 1.0 x 10(-5)-5.0 ng mL(-1), via electrochemical impedance spectroscopy. In terms of preferable stability, operability and repeatability, this biosensor reveals a potentially practical use value for monitoring ATP in real samples. Thus, this work exhibits an effective synthetic strategy to fabricate MOF/GO hybrid composites and further expands their electrochemical sensing applications.