Dietary Iron And Hypoxia Interact To Alter Glucose Homeostasis And Beta-Cell Activity In A Fast Food Diet Mouse Model

Dietary iron overload is linked to increase risk of type 2 diabetes (T2D), with iron significantly affecting insulin sensitivity/secretion, hepatic glucose production, as well as other physiological responses altered in T2D. These effects are in part mediated through the iron-dependent hypoxia sensing pathway. The interactions between iron and hypoxia in T2D have yet to be elucidated. We therefore fed mice a fast food (FF) diet with varying iron concentrations, from a low 4 mg/kg to a high 2000 mg/kg, under normoxic and hypoxic conditions. There was a reduction in weight for hypoxic mice (by 30% for 4mg-Fe diet, 20% for 35mg-Fe diet, and 15% for 2000mg-Fe diet; p Disclosure A.V. Harrison: None. S.T. Sink: None. F. Lorenzo: None. S. Jain: None. D.A. McClain: None.