Multidisciplinary Team Care Delays The Initiation Of Renal Replacement Therapy In Diabetes: A Five-Year Prospective, Single-Center Study
INTERNAL MEDICINE(2021)
摘要
Objective Although recent reports have highlighted the benefits of multidisciplinary team care (MTC) for chronic kidney disease (CKD) in slowing the progress of renal insufficiency, its long-term effects have not been evaluated for patients with diabetes mellitus (DM). We compared the renal survival rate between MTC and conservative care (CC).Methods In this five-year, single-center, prospective, observational study, we examined 24 patients (mean age 65.5 +/- 12.1 years old, men/women 18/6) with DM-induced CKD stage >= 3 in an MTC clinic. The control group included 24 random patients with DM (mean age 61.0 +/- 12.8 years old, men/women 22/2) who received CC. MTC was provided by a nephrologist and medical staff, and CC was provided by a nephrologist.Results In total, 10 MTC and 20 CC patients experienced renal events [creatinine doubling, initiation of renal replacement therapy (RRT), or death due to end-stage CKD]. During the five-year observation period, there were significantly fewer renal events in the MTC group than in the CC group according to the cumulative incidence method (p=0.006). Compared to CC, MTC significantly reduced the need for urgent initiation of hemodialysis (relative risk reduction 0.79, 95% confidence interval [CI] 0.107-0.964). On a multivariate analysis, MTC (hazard ratio [HR], 0.434, 95% CI 0.200-0.939) and the slope of the estimated glomerular filtration rate during the first year (HR, 0.429 per 1 mL/min/m(2)/year, 95% CI 0.279-0.661) were negatively associated with renal events.Conclusion MTC for DM-induced CKD is an effective strategy for delaying RRT. Long-term MTC can demonstrate reno-protective effects.
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关键词
chronic kidney disease, diabetic nephropathy, multidisciplinary team care, renal replacement therapy, urgent initiation of renal replacement therapy, end-stage renal disease
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