A Double-Blind, Randomized, Placebo-Controlled Trial of Ondansetron to reduce vomiting in children receiving Intranasal Fentanyl and Nitrous Oxide for procedural sedation (the FON trial)

Purpose Intranasal fentanyl and nitrous oxide are increasingly combined to provide procedural sedation and analgesia in the pediatric emergency setting. This regimen is attractive due to its non-parenteral administration, but is associated with a higher incidence of vomiting than nitrous oxide alone. We sought to assess whether prophylactic ondansetron use could reduce the incidence of vomiting associated with intranasal fentanyl and nitrous oxide for procedural sedation compared with placebo. …