Syndrome Evolution and Chinese Herb Formula Regularity of TCM Heat Syndrome in Type 2 Diabetes Mellitus - Complex Network Community Discovery Algorithm and Sankey Diagram Visualization.

Objective: Analyzed the evolution of heat syndrome of type 2 diabetes mellitus (T2DM) and the characteristics of Chinese herb formula, in order to provide reference for guiding the clinical practice of T2DM. Methods: Based on the electronic medical record of 2826 patients with T2DM, complex network community discovery algorithm, Sankey diagram and multi-scale backbone network analysis were used to mine the syndrome evolution of different visitand the Chinese herb formula different syndrome groups. Results: In this paper, the complex network of T2DM syndrome was divided into seven main communities (represented by A∼G). Among them, three heat syndrome communities were spleen deficiency and stomach heat syndrome (community B, 16.38% nodes of network), phlegm-heat syndrome (community C, 16.1%) and damp-heat syndrome (community D, 10.17%), accounting for 47.04%. Most of the patients diagnosed with group B, C and D had no change in syndrome for a long-term visit, followed by conversion to group A. Specifically, patients in group B were easier to transform to syndrome community A and C, while group C were likely to transform to syndrome community A and B. Community D had potential to turn into syndrome community A, C, B. The core herb of T2DM heat syndrome was Coptidis Rhizoma, and the mostly herb compatible with it were Zingiberis Rhizoma, Pinelliae Rhizoma, Rehmanniae Radix, Scutellariae Radix, Phellodendri Chinensis Cortex, Anemarrhenae Rhizoma, et al. Conclusion: Qi-yin deficiency syndrome is the common evolution direction of T2DM heat syndrome, and The traditional Chinese medicine commonly used in T2DM heat syndrome is Coptidis Rhizoma.