Therapeutics role of neem and its bioactive constituents in disease prevention and treatment

Azadirachta indica, commonly known as Neem, it is a member of the Meliaceae family. It has gained research interest worldwide prominence in recent years due to its wide range of medicinal properties such as it is rich source of antioxidant and other valuable active compounds such as azadirachtin, nimbolinin, nimbin, nimbidin, nimbidol, salannin, and quercetin isolated from different plant parts. Neem has been extensively used in Ayurveda, Unani and Homeopathic medicines worldwide especially in Indian Subcontinent in the treatment and prevention of various diseases. Neem plays role as free radical scavenging properties, prevention of disease pathogenesis antibacterial, antifungal and anti-inflammatory. It also play a key role as anticancerous agent, antipyretic, hypolgcemic, antigastric ulcer, and antitumour activities. In the present review we have summarized the role of Azadirachta indica in the prevention and treatment of diseases via the regulation of various biological and physiological pathways.