Cafeteria Diet From Birth To Adulthood Promotes Hepatic Steatosis And Redox Imbalance In Wistar Rats

Purpose The purpose of this paper is to evaluate the pathological, biochemical and redox state parameters of liver tissue in Wistar rats treated from birth to adulthood (119 days) with cafeteria diet. Design/methodology/approach During the lactation, 6 liters of Wistar rats (dam + 8 pups each) were fed one of two diets: control (CTRL;n= 3) or cafeteria (CAF;n= 3) diets and water ad libitum. After weaning, the males were placed in individual cages, receiving the same diet offered to their respective dams (CTRL or CAF;n= 18) until adulthood. The following parameters were evaluated: absolute and relative liver weight; blood, liver and feces biochemistry; liver histology; and redox state of the liver. Findings When assessing the relative and absolute organ weight, no significant differences were found between the groups. The Cafeteria group exhibited higher values of serum LDL-c (p= 0.008), VLDL-c (p= 0.03) and triglycerides (p= 0.01), as well as several micro and macrovacuoles of fat accumulation, higher hepatic lipid (p= 0.03) and cholesterol (p= 0.0001) levels regarding Control group. Cafeteria group showed greater expression of glutathione-s-transferase (p= 0.03) and superoxide dismutase (p= 0.005) enzymes compared to the control group. In the case of the markers of oxidative stress, there was no difference between the groups. Originality/value A simple and standardized cafeteria diet caused an accumulation of fatty acids in liver tissue, inducing a state of hepatic steatosis besides an increased expression of antioxidant enzymes.