Primary Conservative Therapy for Symptomatic Isolated Mesenteric Artery Dissection with Severely Compressed True Lumen or Large Dissecting Aneurysm

Purpose: To investigate the safety and effectiveness of primary conservative therapy for patients with symptomatic isolated mesenteric artery dissection (IMAD) with a severely compressed true lumen and/or a large dissecting aneurysm.Materials and Methods: A total of 35 consecutive patients (all men; median age. 53 y) with symptomatic IMAD with a severely compressed true lumen andior a large dissecting aneurysm hut without intestinal necrosis or arterial rupture who were treated with primary conservative therapy between November 2018 and February 2020 were assessed. A severely compressed true lumen was defined as luminal stenosis > 70%. A large dissecting aneurysm was defined as dissecting aneurysm diameter >= 1.5 nines larger than the normal mesenteric artery diameter.Results: There was a strong positive relationship among abdominal pain, degree of luminal stenosis, and length of dissection (R = 0.811; P < .001). Conservative treatment was successful in all patients. Abdominal pain was eliminated within 4.7 d +/- 4.8 (range, 2-31 d) in all patients, within 3.6 d +/- 1.2 (range, 2-6) in the 31 patients with minor or moderate abdominal pain, and within 13.3 d +/- 11.9 (range, 6-31 d) in the 4 patients with severe abdominal pain. Complete or partial remodeling of the mesenteric artery was achieved in 6 (17.1%) and 29 (82.9%) patients, respectively. during 8.6 mo +/- 4.3 of follow-up.Conclusions: Primary conservative therapy can he used safely and effectively in patients with symptomatic IMAD with a severely compressed true lumen and/or a large dissecting aneurysm but without intestinal necrosis or arterial rupture