Highly Accelerated Submillimeter Resolution 3d Grase With Controlled T-2 Blurring In T-2-Weighted Functional Mri At 7 Tesla: A Feasibility Study

Purpose: To achieve highly accelerated submillimeter resolution T-2-weighted functional MRI at 7T by developing a three-dimensional gradient and spin echo imaging (GRASE) with inner-volume selection and variable flip angles (VFA).Methods: GRASE imaging has disadvantages in that (a) k-space modulation causes T-2 blurring by limiting the number of slices and (b) a VFA scheme results in partial success with substantial SNR loss. In this work, accelerated GRASE with controlled T-2 blurring is developed to improve a point spread function (PSF) and temporal signal-to-noise ratio (ISNR) with a large number of slices. To this end, the VFA scheme is designed by minimizing a trade-off between SNR and blurring for functional sensitivity, and a new GRASE-optimized random encoding, which takes into account the complex signal decays of T-2 and T-2* weightings, is proposed by achieving incoherent aliasing for constrained reconstruction. Numerical and experimental studies were performed to validate the effectiveness of the proposed method over regular and VFA GRASE (R- and V-GRASE).Results: The proposed method, while achieving 0.8 mm isotropic resolution, functional MRI compared to R- and V-GRASE improves the spatial extent of the excited volume up to 36 slices with 52%-68% full width at half maximum (FWHM) reduction in PSF but approximately 2- to 3-fold mean tSNR improvement, thus resulting in higher BOLD activations.Conclusions: We successfully demonstrated the feasibility of the proposed method in T-2-weighted functional MRI. The proposed method is especially promising for cortical layer-specific functional MRI.