An clinical analysis of gastrointestinal stromal tumors

Objective\r\nTo evaluate the clinical characteristics, pathology, treatment and prognosis of gastrointestinal stromal tumors.\r\n\r\n\r\nMethods\r\nA retrospective analysis was made on clinical data of 469 patients with gastrointestinal stromal tumors (GIST) admitted between January 2010 and August 2016.\r\n\r\n\r\nResults\r\nThere were 231 males and 238 females, the median age was 57 years old. The tumor was located in the esophagus in 6 cases (1.3%), in the stomach in 295 cases (62.9%), in the duodenum in 23 cases (4.9%), in the small intestine in 69 cases(14.7%), in the colorectum in 26 cases (5.5%). There were altogether 50 cases (10.6%) in this group with a final diagnosis of extra-gastrointestinal stromal tumors. Tumor invasion depth, risk of ulcer caused bleeding and NIH classification varied with its locations (all P\u003c0.05).\r\n\r\n\r\nConclusions\r\nThe clinical characteristics of gastrointestinal stromal tumors can be used to preliminarily predict its malignant degree. Surgical resection is the treatment of choice, and postoperative recurrence or metastases of gastrointestinal stromal tumors can be treated by imatinib.\r\n\r\n\r\nKey words: \r\nGastrointestinal stromal tumors; Pathology, clinical; Operative procedures, surgical